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KMID : 0383820110700010069
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Tuberculosis and Respiratory Diseases
2011 Volume.70 No. 1 p.69 ~ p.73
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A Case of Interstitial Pneumonitis and Pancytopenia Following the Combination Therapy of Pegylated Interferon and Ribavirin
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Seo Ji-Hyun
Hahn Sung-Hwhan
Lee Ji-Eun
Han Jin-Hyung
Kim Kyung-Mook
Kim Do-Hyung
Kim Youn-Seup
Park Jae-Seuk
Jee Young-Koo
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Abstract
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The combination therapy of pegylated interferon and ribavirin is the mainstay of treatment for chronic hepatitis C patients. Anti-viral therapy is commonly associated with side effects such as headache, fever, myalgia, and arthralgia. However, anti-viral therapy can continue because these side effects are mostly mild and can be improved with supportive management. Anti-viral therapy should be stopped promptly if serious side effects, such as interstitial pneumonitis or hemolytic anemia occur, although those serious side effects are rare. There were a few case reports of interferon-related interstitial pneumonitis worldwide. In Korea, one atypical case report of interstitial pneumonitis has been reported, which followed the combination therapy of interferon-alpha and ribavirin in a patient with chronic hepatitis C. We present a case of interstitial pneumonitis and pancytopenia following the combination therapy of pegylated interferon and ribavirin in a patient with chronic hepatitis C.
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KEYWORD
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Hepatitis C, Chronic, peginterferon alfa-2a, Ribavirin, Pancytopenia, Interstitial Lung Diseases
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